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ONDANSETRON
(Zofran)

Ondansetron

PACKAGED: 4 mg in 2 ml vial, (2 mg/ml) (1 in drug bag)

LOCATION: Main Compartment

INDICATION:
For nausea or active vomiting

ADULT: 
Consider Ondansetron 4 mg slow IV, preferred route for active vomiting as pt may need hydration. If no IV, may use 4 mg dissolving tablet or administer the IV form PO.

PEDI:
Ondansetron  0.1  mg/kg IV (max 4 mg).

THERAPEUTIC ACTION:
Stimulation of 5-HT 3 receptors causes transmission of sensory signals to the vomiting center via vagal afferent fibers to induce vomiting.  By binding to 5-HT 3 receptors, Ondansetron blocks vomiting mediated by serotonin release.

CONTRAINDICATION:
Known hypersensitivity to Ondansetron

PRECAUTIONS AND SIDE EFFECTS:
Sudden blindness of 2-3 minute duration has occurred. It is suggested that the speed of delivery may contribute to the blindness.
Constipation, diarrhea, fever, headache

REQUIRES MCP:
ADULT: No 
PEDI: No